James Humble  James Humble photo       

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Computational Neuroscience, Neuron and Brain Modeling
Thomas J. Watson Research Center, Yorktown Heights, NY USA
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Professional Associations:  Society for Neuroscience

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James joined IBM research in 2016. He is currently working to elucidate functions of gamma oscillations and endocannabinoid plasticity in Huntington's Disease and Alzheimer's Disease.

  • Feedback: Exploring the contribution of feedback signals from the cortex to the striatum in health and disease, specifically Huntington's Disease.
  • Synaptic plasticity and homeostasis: The corticostriatal synapse and recurrent synapses within the striatum are implicated in Huntington's disease, so modeling the synaptic plasticity of these synapses may elucidate an important substrate for this disease. Specifically, the endocannabinoid system may play a key role.
  • Oscillations: Experimental observations suggest that oscillations in neural activity are abnormal in both Huntington's Disease and Alzheimer's Disease. Exploring possible substrates for these may garner further understanding of these diseases.

James graduated with a BSc from The University of Plymouth, UK, and then completed a MSc at The University of Manchester, UK. While at Manchester James explored a model of spike-timing-dependent plasticity in the visual system and used a Bayesian model of Drosophila larvae to elucidate the spike code employed in the early stages of the olfactory system.

Following these he completed a PhD at The University of Plymouth, UK, exploring spike-timing-dependent plasticity and explored novel learning rules under learning scenarios in computational spiking neuron models.

James then moved to RIKEN Brain Science Institute in Japan and completed a postdoc looking at the combination of activity-dependent plasticity with activity-independent spine dynamics in health and disease.